Data-driven assessment of the association of polymorphisms in 5-Fluorouracil metabolism genes with outcome in adjuvant treatment of colorectal cancer.

Sarac, Sinan B; Rasmussen, Christian H; Afzal, Shoaib; Thirstrup, Steffen; Jensen, Søren A; Colding-Jørgensen, Morten; Poulsen, Henrik E; Mosekilde, Erik

Sarac, Sinan B; Rasmussen, Christian H; Afzal, Shoaib; Thirstrup, Steffen; Jensen, Søren A; Colding-Jørgensen, Morten; Poulsen, Henrik E; Mosekilde, Erik.

Affiliation

Sarac SB; Novo Nordisk A/S, Bagsvaerd, Denmark. sbsarac@gmail.com

Basic Clin Pharmacol Toxicol ; 111(3): 189-97, 2012 Sep.

Article in En | MEDLINE | ID: mdl-22448752

Subject(s)

Adjuvants, Pharmaceutic/pharmacology; Colorectal Neoplasms/drug therapy; Colorectal Neoplasms/genetics; Fluorouracil/pharmacokinetics; Fluorouracil/therapeutic use; Polymorphism, Genetic; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Cohort Studies; Dihydrouracil Dehydrogenase (NADP)/genetics; Dihydrouracil Dehydrogenase (NADP)/metabolism; Endpoint Determination; Female; Humans; Male; Middle Aged; Risk Assessment; Thymidylate Synthase/genetics; Thymidylate Synthase/metabolism; Treatment Outcome; Young Adult

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Full text: 1 Database: MEDLINE Main subject: Polymorphism, Genetic / Colorectal Neoplasms / Adjuvants, Pharmaceutic / Fluorouracil Type of study: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Language: En Journal: Basic Clin Pharmacol Toxicol Year: 2012 Type: Article Affiliation country: Denmark

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