A polyphenol extract of Hibiscus sabdariffa L. ameliorates acetaminophen-induced hepatic steatosis by attenuating the mitochondrial dysfunction in vivo and in vitro.

Lee, Chao-Hsin; Kuo, Chih-Yi; Wang, Chau-Jong; Wang, Chi-Ping; Lee, Yi-Ru; Hung, Chi-Nan; Lee, Huei-Jane

Lee, Chao-Hsin; Kuo, Chih-Yi; Wang, Chau-Jong; Wang, Chi-Ping; Lee, Yi-Ru; Hung, Chi-Nan; Lee, Huei-Jane.

Affiliation

Lee CH; Division of Orthopaedics, Lee's Medical Corporation, Taichung Hsien, Taiwan.

Biosci Biotechnol Biochem ; 76(4): 646-51, 2012.

Article in En | MEDLINE | ID: mdl-22484925

Subject(s)

Acetaminophen/toxicity; Fatty Liver/prevention & control; Hepatocytes/drug effects; Hibiscus/chemistry; Mitochondria/drug effects; Plant Extracts/therapeutic use; Polyphenols/therapeutic use; Animals; Antioxidants/metabolism; Apoptosis Regulatory Proteins; Catalase/metabolism; Cell Death/drug effects; Fatty Liver/chemically induced; Glutathione/metabolism; Hepatocytes/metabolism; Hepatocytes/pathology; Lipid Peroxidation/drug effects; Liver/drug effects; Liver/metabolism; Liver/pathology; Male; Mice; Mice, Inbred BALB C; Mitochondria/metabolism; Oxidative Stress/drug effects; Plant Extracts/administration & dosage; Polyphenols/administration & dosage

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Database: MEDLINE Therapeutic Methods and Therapies TCIM: Terapias_biologicas Main subject: Plant Extracts / Hepatocytes / Hibiscus / Fatty Liver / Polyphenols / Acetaminophen / Mitochondria Language: En Journal: Biosci Biotechnol Biochem Year: 2012 Type: Article Affiliation country: Taiwan

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