Molecular docking and enzyme kinetic studies of dihydrotanshinone on metabolism of a model CYP2D6 probe substrate in human liver microsomes.

Zhou, Xuelin; Wang, Yan; Or, Penelope M Y; Wan, David C C; Kwan, Yiu Wa; Yeung, John H K

Zhou, Xuelin; Wang, Yan; Or, Penelope M Y; Wan, David C C; Kwan, Yiu Wa; Yeung, John H K.

Affiliation

Zhou X; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.

Phytomedicine ; 19(7): 648-57, 2012 May 15.

Article in En | MEDLINE | ID: mdl-22541637

Subject(s)

Abietanes/pharmacology; Cytochrome P-450 CYP2D6 Inhibitors; Drugs, Chinese Herbal/pharmacology; Herb-Drug Interactions; Microsomes, Liver/drug effects; Phenanthrolines/pharmacology; Salvia miltiorrhiza/chemistry; Abietanes/chemistry; Amino Acids/metabolism; Dextromethorphan/metabolism; Dextrorphan/metabolism; Drugs, Chinese Herbal/chemistry; Humans; Kinetics; Microsomes, Liver/enzymology; Microsomes, Liver/metabolism; Phenanthrolines/chemistry; Protein Binding; Quinidine/chemistry; Quinidine/pharmacology

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Full text: 1 Database: MEDLINE Traditional Medicines: Medicinas_tradicionales_de_asia / Medicina_china Main subject: Phenanthrolines / Microsomes, Liver / Drugs, Chinese Herbal / Salvia miltiorrhiza / Abietanes / Herb-Drug Interactions / Cytochrome P-450 CYP2D6 Inhibitors Language: En Journal: Phytomedicine Year: 2012 Type: Article Affiliation country: China

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