Alstiphyllanines I-O, ajmaline type alkaloids from Alstonia macrophylla showing vasorelaxant activity.

Arai, Hiroko; Zaima, Kazumasa; Mitsuta, Erika; Tamamoto, Haruka; Saito, Aiko; Hirasawa, Yusuke; Rahman, Abdul; Kusumawati, Idha; Zaini, Noor Cholies; Morita, Hiroshi

Arai, Hiroko; Zaima, Kazumasa; Mitsuta, Erika; Tamamoto, Haruka; Saito, Aiko; Hirasawa, Yusuke; Rahman, Abdul; Kusumawati, Idha; Zaini, Noor Cholies; Morita, Hiroshi.

Affiliation

Arai H; Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa, Tokyo 142-8501, Japan.

Bioorg Med Chem ; 20(11): 3454-9, 2012 Jun 01.

Article in En | MEDLINE | ID: mdl-22560833

Subject(s)

Ajmaline/analogs & derivatives; Ajmaline/chemistry; Alstonia/chemistry; Secologanin Tryptamine Alkaloids/chemistry; Secologanin Tryptamine Alkaloids/pharmacology; Vasodilator Agents/chemistry; Vasodilator Agents/pharmacology; Ajmaline/pharmacology; Animals; Aorta/drug effects; Aorta/metabolism; Calcium/metabolism; Calcium Channel Blockers/pharmacology; Calcium Channels/metabolism; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Endothelial Cells/drug effects; Endothelial Cells/metabolism; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Molecular Structure; Nitric Oxide/metabolism; Phenylephrine/pharmacology; Rats; Rats, Wistar; Structure-Activity Relationship; Vasodilation/drug effects

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Full text: 1 Database: MEDLINE Main subject: Vasodilator Agents / Alstonia / Secologanin Tryptamine Alkaloids / Ajmaline Language: En Journal: Bioorg Med Chem Year: 2012 Type: Article Affiliation country: Japan

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