Inhibition of mitochondrial complex I by various non-steroidal anti-inflammatory drugs and its protection by quercetin via a coenzyme Q-like action.

Sandoval-Acuña, Cristian; Lopez-Alarcón, Camilo; Aliaga, Margarita E; Speisky, Hernán

Sandoval-Acuña, Cristian; Lopez-Alarcón, Camilo; Aliaga, Margarita E; Speisky, Hernán.

Affiliation

Sandoval-Acuña C; Nutrition and Food Technology Institute, University of Chile, Santiago, Chile.

Chem Biol Interact ; 199(1): 18-28, 2012 Jul 30.

Article in En | MEDLINE | ID: mdl-22652335

Subject(s)

Anti-Inflammatory Agents, Non-Steroidal/pharmacology; Electron Transport Complex I/antagonists & inhibitors; Mitochondria/metabolism; Quercetin/pharmacology; Ubiquinone/metabolism; Animals; Anti-Inflammatory Agents, Non-Steroidal/adverse effects; Aspirin/pharmacology; Caco-2 Cells; Diclofenac/pharmacology; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Electron Transport Complex I/metabolism; Humans; Ibuprofen/pharmacology; Indomethacin/pharmacology; Mitochondria/drug effects; Multienzyme Complexes/metabolism; NAD/pharmacology; Piroxicam/pharmacology; Protective Agents/pharmacology; Rats; Ubiquinone/pharmacology

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Full text: 1 Database: MEDLINE Main subject: Quercetin / Anti-Inflammatory Agents, Non-Steroidal / Ubiquinone / Electron Transport Complex I / Mitochondria Language: En Journal: Chem Biol Interact Year: 2012 Type: Article Affiliation country: Chile

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