Identification of the plant steroid &#945;-spinasterol as a novel transient receptor potential vanilloid 1 antagonist with antinociceptive properties.

Trevisan, Gabriela; Rossato, Mateus Fortes; Walker, Cristiani Isabel Banderó; Klafke, Jonatas Zeni; Rosa, Fernanda; Oliveira, Sara Marchesan; Tonello, Raquel; Guerra, Gustavo Petri; Boligon, Aline Augusti; Zanon, Ricardo Basso; Athayde, Margareth Linde; Ferreira, Juliano

Identification of the plant steroid α-spinasterol as a novel transient receptor potential vanilloid 1 antagonist with antinociceptive properties.

Trevisan, Gabriela; Rossato, Mateus Fortes; Walker, Cristiani Isabel Banderó; Klafke, Jonatas Zeni; Rosa, Fernanda; Oliveira, Sara Marchesan; Tonello, Raquel; Guerra, Gustavo Petri; Boligon, Aline Augusti; Zanon, Ricardo Basso; Athayde, Margareth Linde; Ferreira, Juliano.

Affiliation

Trevisan G; Departamento de Química, Universidade Federal de Santa Maria, Avenida Roraima, 1000, Camobi, 97105-900, Santa Maria, RS, Brazil. gabitrev@hotmail.com

J Pharmacol Exp Ther ; 343(2): 258-69, 2012 Nov.

Article in En | MEDLINE | ID: mdl-22837009

Subject(s)

Analgesics; Stigmasterol/analogs & derivatives; TRPV Cation Channels/antagonists & inhibitors; Vernonia/chemistry; Animals; Binding, Competitive/drug effects; Body Temperature/drug effects; Calcium/metabolism; Capsaicin/pharmacology; Chromatography, High Pressure Liquid; Diterpenes/metabolism; Edema/chemically induced; Edema/pathology; Freund's Adjuvant; Hot Temperature; Male; Mice; Nociceptors/drug effects; Pain/chemically induced; Pain/prevention & control; Pain Measurement/drug effects; Plant Extracts/chemistry; Plant Extracts/pharmacology; Plant Leaves/chemistry; Stigmasterol/pharmacokinetics; Stigmasterol/pharmacology; Tissue Distribution

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Full text: 1 Database: MEDLINE Main subject: Stigmasterol / Vernonia / TRPV Cation Channels / Analgesics Type of study: Diagnostic_studies / Prognostic_studies Language: En Journal: J Pharmacol Exp Ther Year: 2012 Type: Article Affiliation country: Brazil

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