Loss of Maged1 results in obesity, deficits of social interactions, impaired sexual behavior and severe alteration of mature oxytocin production in the hypothalamus.

Dombret, Carlos; Nguyen, Tuan; Schakman, Olivier; Michaud, Jacques L; Hardin-Pouzet, Hélène; Bertrand, Mathieu J M; De Backer, Olivier

Dombret, Carlos; Nguyen, Tuan; Schakman, Olivier; Michaud, Jacques L; Hardin-Pouzet, Hélène; Bertrand, Mathieu J M; De Backer, Olivier.

Affiliation

Dombret C; Unité de Recherche en Physiologie Moléculaire, Namur Research Institute for Life Sciences, FUNDP School of Medicine, University of Namur, 61 rue de Bruxelles, Namur B-5000, Belgium.

Hum Mol Genet ; 21(21): 4703-17, 2012 Nov 01.

Article in En | MEDLINE | ID: mdl-22865874

Subject(s)

Neoplasm Proteins; Oxytocin; Prader-Willi Syndrome; Sexual Behavior, Animal; Animals; Anxiety/genetics; Anxiety/metabolism; Anxiety/physiopathology; Autistic Disorder/metabolism; Autistic Disorder/physiopathology; Humans; Hypothalamus/drug effects; Hypothalamus/metabolism; Interpersonal Relations; Mice; Neoplasm Proteins/deficiency; Neoplasm Proteins/genetics; Neoplasm Proteins/metabolism; Obesity/genetics; Obesity/metabolism; Obesity/physiopathology; Oxytocin/administration & dosage; Oxytocin/biosynthesis; Oxytocin/metabolism; Prader-Willi Syndrome/genetics; Prader-Willi Syndrome/metabolism; Prader-Willi Syndrome/physiopathology; Sexual Behavior, Animal/drug effects; Sexual Behavior, Animal/physiology

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Full text: 1 Database: MEDLINE Main subject: Prader-Willi Syndrome / Sexual Behavior, Animal / Oxytocin / Neoplasm Proteins Language: En Journal: Hum Mol Genet Year: 2012 Type: Article Affiliation country: Belgium

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