Estrogen receptor potentiates mTORC2 signaling in breast cancer cells by upregulating superoxide anions.

Kumari Kanchan, Ranjana; Tripathi, Chakrapani; Singh Baghel, Khemraj; Kumar Dwivedi, Shailendra; Kumar, Balawant; Sanyal, Sabyasachi; Sharma, Sharad; Mitra, Kalyan; Garg, Vivek; Singh, Kavita; Sultana, Sarwat; Kamal Tripathi, Raj; Kumar Rath, Srikanta; Bhadauria, Smrati

Kumari Kanchan, Ranjana; Tripathi, Chakrapani; Singh Baghel, Khemraj; Kumar Dwivedi, Shailendra; Kumar, Balawant; Sanyal, Sabyasachi; Sharma, Sharad; Mitra, Kalyan; Garg, Vivek; Singh, Kavita; Sultana, Sarwat; Kamal Tripathi, Raj; Kumar Rath, Srikanta; Bhadauria, Smrati.

Affiliation

Kumari Kanchan R; Division of Toxicology, Central Drug Research Institute (CSIR), India.

Free Radic Biol Med ; 53(10): 1929-41, 2012 Nov 15.

Article in En | MEDLINE | ID: mdl-23000059

Subject(s)

Breast Neoplasms/metabolism; Multiprotein Complexes/metabolism; Reactive Oxygen Species/metabolism; Receptors, Estrogen/metabolism; Superoxides/metabolism; TOR Serine-Threonine Kinases/metabolism; Cell Line, Tumor; Disease Progression; Estradiol/pharmacology; Female; Humans; MCF-7 Cells; Mechanistic Target of Rapamycin Complex 2; Mitochondria/metabolism; Oxidation-Reduction; RNA Interference; RNA, Small Interfering; Signal Transduction/physiology; Superoxide Dismutase/genetics; Superoxide Dismutase/metabolism; Up-Regulation

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Full text: 1 Database: MEDLINE Main subject: Breast Neoplasms / Receptors, Estrogen / Reactive Oxygen Species / Superoxides / Multiprotein Complexes / TOR Serine-Threonine Kinases Language: En Journal: Free Radic Biol Med Year: 2012 Type: Article Affiliation country: India

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