Angiogenesis Inhibitors/therapeutic use; Hypoxia/metabolism; Macular Degeneration/prevention & control; Phosphatidylinositol 3-Kinases/metabolism; Proto-Oncogene Proteins c-akt/metabolism; Silymarin/therapeutic use; TOR Serine-Threonine Kinases/metabolism; Vascular Endothelial Growth Factor A/metabolism; Angiogenesis Inhibitors/administration & dosage; Animals; Autophagy/drug effects; Blotting, Western; Cell Hypoxia/physiology; Cells, Cultured; Disease Models, Animal; Epithelial Cells/drug effects; Epithelial Cells/metabolism; Humans; Hypoxia/complications; Hypoxia/enzymology; Hypoxia-Inducible Factor 1/biosynthesis; Hypoxia-Inducible Factor 1/metabolism; Macular Degeneration/enzymology; Macular Degeneration/metabolism; Rats; Rats, Inbred BN; Retinal Pigment Epithelium/cytology; Retinal Pigment Epithelium/drug effects; Signal Transduction; Silybin; Silymarin/administration & dosage; Vascular Endothelial Growth Factor A/administration & dosage; Vascular Endothelial Growth Factor A/biosynthesis