Targeting the DNA-binding activity of the human ERG transcription factor using new heterocyclic dithiophene diamidines.

Nhili, Raja; Peixoto, Paul; Depauw, Sabine; Flajollet, Sébastien; Dezitter, Xavier; Munde, Manoj M; Ismail, Mohamed A; Kumar, Arvind; Farahat, Abdelbasset A; Stephens, Chad E; Duterque-Coquillaud, Martine; David Wilson, W; Boykin, David W; David-Cordonnier, Marie-Hélène

Nhili, Raja; Peixoto, Paul; Depauw, Sabine; Flajollet, Sébastien; Dezitter, Xavier; Munde, Manoj M; Ismail, Mohamed A; Kumar, Arvind; Farahat, Abdelbasset A; Stephens, Chad E; Duterque-Coquillaud, Martine; David Wilson, W; Boykin, David W; David-Cordonnier, Marie-Hélène.

Affiliation

Nhili R; INSERM UMR837-JPARC, Team 4, Molecular and Cellular Targeting for Cancer Treatment, University of Lille North of France, IMPRT-IFR114, Institut pour la Recherche sur le Cancer de Lille, Place de Verdun, Lille F-59045, France.

Nucleic Acids Res ; 41(1): 125-38, 2013 Jan 07.

Article in En | MEDLINE | ID: mdl-23093599

Subject(s)

Amidines/pharmacology; Antineoplastic Agents/pharmacology; Thiophenes/pharmacology; Trans-Activators/antagonists & inhibitors; Transcriptional Activation/drug effects; Amidines/chemistry; Amidines/metabolism; Antineoplastic Agents/chemistry; Antineoplastic Agents/metabolism; Binding Sites; Cell Line, Tumor; DNA/chemistry; DNA/metabolism; Drug Evaluation, Preclinical; Humans; Thiophenes/chemistry; Thiophenes/metabolism; Trans-Activators/metabolism; Transcriptional Regulator ERG

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Full text: 1 Database: MEDLINE Main subject: Thiophenes / Transcriptional Activation / Trans-Activators / Amidines / Antineoplastic Agents Language: En Journal: Nucleic Acids Res Year: 2013 Type: Article Affiliation country: France

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