Both selenium deficiency and modest selenium supplementation lead to myocardial fibrosis in mice via effects on redox-methylation balance.

Metes-Kosik, Nicole; Luptak, Ivan; Dibello, Patricia M; Handy, Diane E; Tang, Shiow-Shih; Zhi, Hui; Qin, Fuzhong; Jacobsen, Donald W; Loscalzo, Joseph; Joseph, Jacob

Metes-Kosik, Nicole; Luptak, Ivan; Dibello, Patricia M; Handy, Diane E; Tang, Shiow-Shih; Zhi, Hui; Qin, Fuzhong; Jacobsen, Donald W; Loscalzo, Joseph; Joseph, Jacob.

Affiliation

Metes-Kosik N; VA Boston Healthcare System, West Roxbury, MA 02132, USA.

Mol Nutr Food Res ; 56(12): 1812-24, 2012 Dec.

Article in En | MEDLINE | ID: mdl-23097236

Subject(s)

Cardiomyopathies/drug therapy; DNA Methylation/drug effects; Dietary Supplements; Myocardium/pathology; Oxidative Stress/drug effects; Selenium/deficiency; Selenium/pharmacology; Animals; Cardiomyopathies/physiopathology; Cysteine/blood; Diet; Epigenomics; Fibrosis; Glutathione/blood; Homocysteine/blood; Isoprostanes/blood; Male; Mice; Mice, Inbred C57BL; Real-Time Polymerase Chain Reaction; Selenium/blood; Selenoproteins/genetics; Selenoproteins/metabolism

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Full text: 1 Database: MEDLINE Main subject: Selenium / Oxidative Stress / DNA Methylation / Dietary Supplements / Cardiomyopathies / Myocardium Language: En Journal: Mol Nutr Food Res Year: 2012 Type: Article Affiliation country: United States

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