Mice expressing the ADNFLE valine 287 leucine mutation of the &#914;2 nicotinic acetylcholine receptor subunit display increased sensitivity to acute nicotine administration and altered presynaptic nicotinic receptor function.

O'Neill, Heidi C; Laverty, Duncan C; Patzlaff, Natalie E; Cohen, Bruce N; Fonck, Carlos; McKinney, Sheri; McIntosh, J Michael; Lindstrom, Jon M; Lester, Henry A; Grady, Sharon R; Marks, Michael J

Mice expressing the ADNFLE valine 287 leucine mutation of the Β2 nicotinic acetylcholine receptor subunit display increased sensitivity to acute nicotine administration and altered presynaptic nicotinic receptor function.

O'Neill, Heidi C; Laverty, Duncan C; Patzlaff, Natalie E; Cohen, Bruce N; Fonck, Carlos; McKinney, Sheri; McIntosh, J Michael; Lindstrom, Jon M; Lester, Henry A; Grady, Sharon R; Marks, Michael J.

Affiliation

O'Neill HC; Institute for Behavioral Genetics, 447 UCB, University of Colorado, Boulder, CO 80309, USA. heidi.oneill@colorado.edu

Pharmacol Biochem Behav ; 103(3): 603-21, 2013 Jan.

Article in En | MEDLINE | ID: mdl-23123803

Subject(s)

Central Nervous System Sensitization/physiology; Nicotine/pharmacology; Presynaptic Terminals/physiology; Receptors, Nicotinic/physiology; Acetylcholine/pharmacology; Animals; Body Temperature/drug effects; Body Temperature/genetics; Body Temperature/physiology; Central Nervous System Sensitization/genetics; Cerebral Cortex/drug effects; Cerebral Cortex/metabolism; Dopamine/metabolism; Dystonia/chemically induced; Dystonia/genetics; Dystonia/physiopathology; Gene Knock-In Techniques; Hippocampus/drug effects; Hippocampus/metabolism; Male; Mice; Motor Activity/drug effects; Motor Activity/genetics; Motor Activity/physiology; Mutation, Missense/genetics; Nicotine/administration & dosage; Presynaptic Terminals/drug effects; Radioligand Assay/methods; Receptors, Nicotinic/biosynthesis; Receptors, Nicotinic/genetics; Rubidium Radioisotopes; Seizures/chemically induced; Seizures/genetics; Seizures/metabolism; Seizures/physiopathology; Synaptosomes/drug effects; Synaptosomes/metabolism; gamma-Aminobutyric Acid/metabolism

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Full text: 1 Database: MEDLINE Main subject: Receptors, Nicotinic / Presynaptic Terminals / Central Nervous System Sensitization / Nicotine Type of study: Diagnostic_studies Language: En Journal: Pharmacol Biochem Behav Year: 2013 Type: Article Affiliation country: United States

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