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Changes of the serum cytokine contents in broilers fed on diets supplemented with nickel chloride.
Wu, Bangyuan; Cui, Hengmin; Peng, Xi; Fang, Jing; Zuo, Zhicai; Huang, Jianying; Luo, Qin; Deng, Yubing; Wang, Hesong; Liu, Juan.
Affiliation
  • Wu B; Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an, China.
Biol Trace Elem Res ; 151(2): 234-9, 2013 Feb.
Article in En | MEDLINE | ID: mdl-23179351
Cytokines are immunoregulatory proteins which play an important role in the immune system. The purpose of this study was to examine the serum cytokine contents including interleukin-2 (IL-2), interleukin-4 (IL-4), interleukin-6 (IL-6), interleukin-10 (IL-10), interferon gamma (IFN-γ), and tumor necrosis factor-alpha (TNF-α) induced by dietary nickel chloride in broilers by enzyme-linked immunospecific assay. A total of 240 one-day-old avian broilers were divided into four groups and fed on a corn-soybean basal diet as control diet or the same basal diet supplemented with 300, 600, and 900 mg/kg of nickel chloride. During the experimental period of 42 days, the results showed that the serum IL-2, IL-4, IL-6, IL-10, IFN-γ and TNF-α contents were lower (p < 0.05 or p < 0.01) in the 300, 600, 900 mg/kg groups than those in the control group. It was concluded that dietary nickel chloride in the range of 300 to 900 mg/kg could reduce the serum cytokine contents, which could finally impact the immune function in broilers.
Subject(s)

Full text: 1 Database: MEDLINE Main subject: Chickens / Cytokines / Dietary Supplements / Nickel Language: En Journal: Biol Trace Elem Res Year: 2013 Type: Article Affiliation country: China

Full text: 1 Database: MEDLINE Main subject: Chickens / Cytokines / Dietary Supplements / Nickel Language: En Journal: Biol Trace Elem Res Year: 2013 Type: Article Affiliation country: China