Blocking protein kinase C signaling pathway: mechanistic insights into the anti-leishmanial activity of prospective herbal drugs from Withania somnifera.

Grover, Abhinav; Katiyar, Shashank Prakash; Jeyakanthan, Jeyaraman; Dubey, Vikash Kumar; Sundar, Durai

Grover, Abhinav; Katiyar, Shashank Prakash; Jeyakanthan, Jeyaraman; Dubey, Vikash Kumar; Sundar, Durai.

Affiliation

Grover A; Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology (IIT) Delhi, Hauz Khas, New Delhi 110016, India.

BMC Genomics ; 13 Suppl 7: S20, 2012.

Article in En | MEDLINE | ID: mdl-23281834

Subject(s)

Antiprotozoal Agents/chemistry; Protein Kinase C/antagonists & inhibitors; Protozoan Proteins/antagonists & inhibitors; Withania/chemistry; Antiprotozoal Agents/isolation & purification; Antiprotozoal Agents/pharmacology; Binding Sites; Catalytic Domain; Herbal Medicine; Leishmania/metabolism; Molecular Docking Simulation; Protein Kinase C/metabolism; Protozoan Proteins/metabolism; Signal Transduction/drug effects; Thermodynamics; Triterpenes/chemistry; Triterpenes/isolation & purification; Triterpenes/pharmacology; Withanolides/chemistry; Withanolides/isolation & purification; Withanolides/pharmacology

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Full text: 1 Database: MEDLINE Main subject: Protein Kinase C / Protozoan Proteins / Withania / Antiprotozoal Agents Type of study: Prognostic_studies / Risk_factors_studies Language: En Journal: BMC Genomics Year: 2012 Type: Article Affiliation country: India

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