Eupatolide inhibits PDGF-induced proliferation and migration of aortic smooth muscle cells through ROS-dependent heme oxygenase-1 induction.

Kim, Namho; Hwangbo, Cheol; Lee, Suhyun; Lee, Jeong-Hyung

Kim, Namho; Hwangbo, Cheol; Lee, Suhyun; Lee, Jeong-Hyung.

Affiliation

Kim N; Department of Biochemistry, College of Natural Sciences, Kangwon National University, Chuncheon, Gangwon-Do, 200-701, Republic of Korea.

Phytother Res ; 27(11): 1700-7, 2013 Nov.

Article in En | MEDLINE | ID: mdl-23297002

Subject(s)

Cell Proliferation/drug effects; Heme Oxygenase (Decyclizing)/metabolism; Myocytes, Smooth Muscle/drug effects; Platelet-Derived Growth Factor/pharmacology; Reactive Oxygen Species/metabolism; Sesquiterpenes/pharmacology; Acetylcysteine/pharmacology; Animals; Anthracenes/pharmacology; Aorta/cytology; Butadienes/pharmacology; Cell Movement/drug effects; Cells, Cultured; Chromones/pharmacology; Enzyme Inhibitors/pharmacology; Heme Oxygenase (Decyclizing)/genetics; Imidazoles/pharmacology; Inula/chemistry; Male; Morpholines/pharmacology; Muscle, Smooth, Vascular/cytology; Muscle, Smooth, Vascular/drug effects; Myocytes, Smooth Muscle/metabolism; NF-E2-Related Factor 2/metabolism; Nitriles/pharmacology; Pyridines/pharmacology; Rats; Rats, Sprague-Dawley

Key words

eupatolide; heme oxygenase-1; migration; proliferation; vascular smooth muscle cell

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Full text: 1 Database: MEDLINE Main subject: Sesquiterpenes / Platelet-Derived Growth Factor / Reactive Oxygen Species / Myocytes, Smooth Muscle / Cell Proliferation / Heme Oxygenase (Decyclizing) Language: En Journal: Phytother Res Year: 2013 Type: Article

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