Oridonin induces apoptosis in gastric cancer through Apaf-1, cytochrome c and caspase-3 signaling pathway.

Sun, Ke-Wang; Ma, Ying-Yu; Guan, Tian-Pei; Xia, Ying-Jie; Shao, Chang-Ming; Chen, Le-Gao; Ren, Ya-Jun; Yao, Hai-Bo; Yang, Qiong; He, Xu-Jun

Sun, Ke-Wang; Ma, Ying-Yu; Guan, Tian-Pei; Xia, Ying-Jie; Shao, Chang-Ming; Chen, Le-Gao; Ren, Ya-Jun; Yao, Hai-Bo; Yang, Qiong; He, Xu-Jun.

Affiliation

Sun KW; Department of Thyroid and Breast Surgery, Zhejiang Provincial People's Hospital, Hangzhou 310014, Zhejiang Province, China.

World J Gastroenterol ; 18(48): 7166-74, 2012 Dec 28.

Article in En | MEDLINE | ID: mdl-23326121

Subject(s)

Apoptosis; Apoptotic Protease-Activating Factor 1/metabolism; Caspase 3/metabolism; Cytochromes c/metabolism; Diterpenes, Kaurane/pharmacology; Stomach Neoplasms/metabolism; Annexin A5/pharmacology; Antineoplastic Agents/pharmacology; Cell Line, Tumor; Cell Proliferation; DNA Fragmentation; Dactinomycin/analogs & derivatives; Dactinomycin/pharmacology; Dose-Response Relationship, Drug; Flow Cytometry; Humans; Isodon/chemistry; Medicine, Chinese Traditional; Microscopy, Fluorescence; Phycoerythrin/pharmacology; Plant Extracts/pharmacology; Signal Transduction; Time Factors

Key words

Apaf-1/caspase-3/cytochrome C; Apoptosis; Gastric cancer; Oridonin; Proliferation

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Full text: 1 Database: MEDLINE Traditional Medicines: Medicinas_tradicionales_de_asia / Medicina_china Therapeutic Methods and Therapies TCIM: Terapias_biologicas Main subject: Stomach Neoplasms / Apoptosis / Diterpenes, Kaurane / Cytochromes c / Caspase 3 / Apoptotic Protease-Activating Factor 1 Type of study: Diagnostic_studies Language: En Journal: World J Gastroenterol Year: 2012 Type: Article Affiliation country: China

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