The anorexigenic effect of serotonin is mediated by the generation of NADPH oxidase-dependent ROS.

Fang, Xin-Ling; Shu, Gang; Yu, Jian-Jian; Wang, Li-Na; Yang, Jing; Zeng, Qing-Jie; Cheng, Xiao; Zhang, Zhi-Qi; Wang, Song-Bo; Gao, Ping; Zhu, Xiao-Tong; Xi, Qian-Yun; Zhang, Yong-Liang; Jiang, Qing-Yan

Fang, Xin-Ling; Shu, Gang; Yu, Jian-Jian; Wang, Li-Na; Yang, Jing; Zeng, Qing-Jie; Cheng, Xiao; Zhang, Zhi-Qi; Wang, Song-Bo; Gao, Ping; Zhu, Xiao-Tong; Xi, Qian-Yun; Zhang, Yong-Liang; Jiang, Qing-Yan.

Affiliation

Fang XL; College of Animal Science, South China Agricultural University, Guangzhou 510642, China.

PLoS One ; 8(1): e53142, 2013.

Article in En | MEDLINE | ID: mdl-23326391

Subject(s)

Eating/drug effects; NADPH Oxidases/metabolism; Reactive Oxygen Species/metabolism; Serotonin/pharmacology; Acetophenones/pharmacology; Animals; Antioxidants/pharmacology; Blotting, Western; Chromans/pharmacology; Gene Expression/drug effects; Glutathione Peroxidase/metabolism; Hypothalamus/drug effects; Hypothalamus/metabolism; Injections, Intraventricular; Ion Channels/genetics; Ion Channels/metabolism; Male; Malondialdehyde/metabolism; Mice; Mitochondrial Proteins/genetics; Mitochondrial Proteins/metabolism; Pro-Opiomelanocortin/genetics; Pro-Opiomelanocortin/metabolism; Reverse Transcriptase Polymerase Chain Reaction; Serotonin/administration & dosage; Serotonin Receptor Agonists/administration & dosage; Serotonin Receptor Agonists/pharmacology; Superoxide Dismutase/metabolism; Uncoupling Protein 2; Uncoupling Protein 3

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Full text: 1 Database: MEDLINE Main subject: Serotonin / Reactive Oxygen Species / NADPH Oxidases / Eating Language: En Journal: PLoS One Year: 2013 Type: Article Affiliation country: China

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