Simvastatin and GGTI-2133, a geranylgeranyl transferase inhibitor, increase erythrocyte deformability but reduce low O(2) tension-induced ATP release.

Clapp, K M; Ellsworth, M L; Sprague, R S; Stephenson, A H

Clapp, K M; Ellsworth, M L; Sprague, R S; Stephenson, A H.

Affiliation

Clapp KM; Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St. Louis, MO 63104, USA. thuetk@slu.edu

Am J Physiol Heart Circ Physiol ; 304(5): H660-6, 2013 Mar 01.

Article in En | MEDLINE | ID: mdl-23335799

Subject(s)

Adenosine Triphosphate/metabolism; Alkyl and Aryl Transferases/antagonists & inhibitors; Erythrocyte Deformability/drug effects; Imidazoles/pharmacology; Leucine/analogs & derivatives; Naphthalenes/pharmacology; Oxygen/metabolism; Simvastatin/pharmacology; Adrenergic beta-Agonists/pharmacology; Adult; Alkyl and Aryl Transferases/metabolism; Animals; Anticholesteremic Agents/pharmacology; Anticholesteremic Agents/therapeutic use; Cholesterol/blood; Erythrocytes/drug effects; Erythrocytes/metabolism; Female; Humans; Intercellular Signaling Peptides and Proteins; Isoproterenol/pharmacology; Leucine/pharmacology; Male; Middle Aged; Nitric Oxide Synthase Type III/metabolism; Partial Pressure; Peptides/pharmacology; Rats; Rats, Sprague-Dawley; Simvastatin/therapeutic use; Wasp Venoms/pharmacology; Young Adult; rho-Associated Kinases/metabolism

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Full text: 1 Database: MEDLINE Main subject: Oxygen / Adenosine Triphosphate / Simvastatin / Alkyl and Aryl Transferases / Erythrocyte Deformability / Imidazoles / Leucine / Naphthalenes Language: En Journal: Am J Physiol Heart Circ Physiol Year: 2013 Type: Article Affiliation country: United States

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