A long-term three dimensional liver co-culture system for improved prediction of clinically relevant drug-induced hepatotoxicity.

Kostadinova, Radina; Boess, Franziska; Applegate, Dawn; Suter, Laura; Weiser, Thomas; Singer, Thomas; Naughton, Brian; Roth, Adrian

Kostadinova, Radina; Boess, Franziska; Applegate, Dawn; Suter, Laura; Weiser, Thomas; Singer, Thomas; Naughton, Brian; Roth, Adrian.

Affiliation

Kostadinova R; Hoffmann-La Roche Ltd, Basel, Switzerland.

Toxicol Appl Pharmacol ; 268(1): 1-16, 2013 Apr 01.

Article in En | MEDLINE | ID: mdl-23352505

Subject(s)

Coculture Techniques/methods; Drug Evaluation, Preclinical/methods; Endothelial Cells/metabolism; Hepatocytes/cytology; Hepatocytes/drug effects; Liver/cytology; Liver/drug effects; Adult; Albumins/metabolism; Animals; Cell Survival/drug effects; Cytochrome P-450 Enzyme System/metabolism; Endothelial Cells/cytology; Enzyme Inhibitors/pharmacology; Fibrinogen/metabolism; Hepatocytes/metabolism; Humans; Liver/metabolism; Male; Middle Aged; Rats; Rats, Wistar; Transferrin/metabolism; Urea/metabolism

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Full text: 1 Database: MEDLINE Main subject: Coculture Techniques / Hepatocytes / Endothelial Cells / Drug Evaluation, Preclinical / Liver Type of study: Prognostic_studies / Risk_factors_studies Language: En Journal: Toxicol Appl Pharmacol Year: 2013 Type: Article Affiliation country: Switzerland

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