N-Alkyldeoxynojirimycin derivatives with novel terminal tertiary amide substitution for treatment of bovine viral diarrhea virus (BVDV), Dengue, and Tacaribe virus infections.

Du, Yanming; Ye, Hong; Gill, Tina; Wang, Lijuan; Guo, Fang; Cuconati, Andrea; Guo, Ju-Tao; Block, Timothy M; Chang, Jinhong; Xu, Xiaodong

Du, Yanming; Ye, Hong; Gill, Tina; Wang, Lijuan; Guo, Fang; Cuconati, Andrea; Guo, Ju-Tao; Block, Timothy M; Chang, Jinhong; Xu, Xiaodong.

Affiliation

Du Y; Institute for Hepatitis and Virus Research, 3805 Old Easton Road, Doylestown, PA 18902, USA. yanming.du@ihvr.org

Bioorg Med Chem Lett ; 23(7): 2172-6, 2013 Apr 01.

Article in En | MEDLINE | ID: mdl-23453839

Subject(s)

Amides/pharmacology; Antiviral Agents/pharmacology; Defective Viruses/drug effects; Dengue/drug therapy; Diarrhea Viruses, Bovine Viral/drug effects; Glucosamine/analogs & derivatives; 1-Deoxynojirimycin/chemical synthesis; 1-Deoxynojirimycin/chemistry; 1-Deoxynojirimycin/pharmacology; Amides/chemical synthesis; Amides/chemistry; Animals; Antiviral Agents/chemical synthesis; Antiviral Agents/chemistry; Cell Line; Cell Survival/drug effects; Cricetinae; Dose-Response Relationship, Drug; Glucosamine/chemical synthesis; Glucosamine/chemistry; Glucosamine/pharmacology; Humans; Molecular Structure; Structure-Activity Relationship

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Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Terapias_biologicas / Aromoterapia Main subject: Antiviral Agents / Diarrhea Viruses, Bovine Viral / Defective Viruses / Dengue / Amides / Glucosamine Language: En Journal: Bioorg Med Chem Lett Year: 2013 Type: Article Affiliation country: United States

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