Hirsutella sinensis mycelium suppresses interleukin-1ß and interleukin-18 secretion by inhibiting both canonical and non-canonical inflammasomes.

Huang, Tsung-Teng; Chong, Kowit-Yu; Ojcius, David M; Wu, Yi-Hui; Ko, Yun-Fei; Wu, Cheng-Yeu; Martel, Jan; Lu, Chia-Chen; Lai, Hsin-Chih; Young, John D

Huang, Tsung-Teng; Chong, Kowit-Yu; Ojcius, David M; Wu, Yi-Hui; Ko, Yun-Fei; Wu, Cheng-Yeu; Martel, Jan; Lu, Chia-Chen; Lai, Hsin-Chih; Young, John D.

Affiliation

Huang TT; Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan, Taiwan, Republic of China.

Sci Rep ; 3: 1374, 2013.

Article in En | MEDLINE | ID: mdl-23459183

Subject(s)

Ascomycota/metabolism; Inflammasomes/antagonists & inhibitors; Interleukin-18/metabolism; Interleukin-1beta/metabolism; Mycelium/metabolism; Adaptor Proteins, Signal Transducing/metabolism; Adenosine Triphosphate/pharmacology; Apoptosis Regulatory Proteins/metabolism; Caspases/metabolism; Down-Regulation/drug effects; Enzyme Activation/drug effects; Ethanol; Humans; Inflammasomes/metabolism; Interleukin-18/genetics; Interleukin-1beta/genetics; Lipopolysaccharides/pharmacology; Macrophage Activation/drug effects; Macrophages/drug effects; Macrophages/enzymology; Macrophages/metabolism; Macrophages/microbiology; Models, Biological; NLR Proteins; Reactive Oxygen Species/metabolism; Receptors, Purinergic P2X4/metabolism; Receptors, Purinergic P2X7/metabolism

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Ascomycota / Interleukin-18 / Mycelium / Interleukin-1beta / Inflammasomes Type of study: Prognostic_studies Language: En Journal: Sci Rep Year: 2013 Type: Article Affiliation country: China

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google