Application of a novel microtitre plate-based assay for the discovery of new inhibitors of DNA gyrase and DNA topoisomerase VI.

Taylor, James A; Mitchenall, Lesley A; Rejzek, Martin; Field, Robert A; Maxwell, Anthony

Taylor, James A; Mitchenall, Lesley A; Rejzek, Martin; Field, Robert A; Maxwell, Anthony.

Affiliation

Taylor JA; Department of Biological Chemistry, John Innes Centre, Colney Lane, Norwich, United Kingdom.

PLoS One ; 8(2): e58010, 2013.

Article in En | MEDLINE | ID: mdl-23469129

Subject(s)

Archaeal Proteins/antagonists & inhibitors; Drug Evaluation, Preclinical/methods; Topoisomerase II Inhibitors; Topoisomerase Inhibitors/pharmacology; Anthraquinones/pharmacology; Arabidopsis/drug effects; Arabidopsis/enzymology; Arabidopsis/growth & development; DNA Topoisomerases, Type II; Drug Evaluation, Preclinical/instrumentation; Escherichia coli/enzymology; Hexylresorcinol/pharmacology; Methanosarcina/enzymology; Mitoxantrone/pharmacology; Quinacrine/pharmacology; Sulfolobus/enzymology; Suramin/pharmacology

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Full text: 1 Database: MEDLINE Main subject: Archaeal Proteins / Drug Evaluation, Preclinical / Topoisomerase Inhibitors / Topoisomerase II Inhibitors Language: En Journal: PLoS One Year: 2013 Type: Article Affiliation country: United kingdom

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