Edema/prevention & control; Endopeptidases/therapeutic use; Enzyme Therapy/methods; Face; Orthognathic Surgical Procedures/methods; Postoperative Complications/prevention & control; Rutin/therapeutic use; Bromelains/therapeutic use; Cephalometry/methods; Chin/diagnostic imaging; Chin/surgery; Double-Blind Method; Drug Combinations; Edema/diagnostic imaging; Face/diagnostic imaging; Female; Follow-Up Studies; Humans; Lip/diagnostic imaging; Male; Mandible/diagnostic imaging; Neck/diagnostic imaging; Osteotomy, Le Fort/methods; Osteotomy, Sagittal Split Ramus/methods; Placebos; Postoperative Complications/diagnostic imaging; Premedication; Prospective Studies; Treatment Outcome; Trypsin/therapeutic use; Ultrasonography; Young Adult