Evaluation of antihepatotoxic potential of Solanum xanthocarpum fruit extract against antitubercular drugs induced hepatopathy in experimental rodents.

Hussain, Talib; Gupta, Ramesh K; K, Sweety; Khan, Mohd Sajid; Hussain, M D Sarfaraj; Arif, M D; Hussain, Arshad; Faiyazuddin, M D; Rao, Chandana Venkateswara

Hussain, Talib; Gupta, Ramesh K; K, Sweety; Khan, Mohd Sajid; Hussain, M D Sarfaraj; Arif, M D; Hussain, Arshad; Faiyazuddin, M D; Rao, Chandana Venkateswara.

Affiliation

Hussain T; Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute, Lucknow, Uttar Pradesh 226001, India ; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Integral University, Lucknow Uttar Pradesh 226001.

Asian Pac J Trop Biomed ; 2(6): 454-60, 2012 Jun.

Article in En | MEDLINE | ID: mdl-23569949

Subject(s)

Antitubercular Agents/toxicity; Chemical and Drug Induced Liver Injury/prevention & control; Fruit/chemistry; Gastrointestinal Agents/administration & dosage; Plant Extracts/administration & dosage; Solanum/chemistry; Animals; Antitubercular Agents/administration & dosage; Disease Models, Animal; Female; Gastrointestinal Agents/isolation & purification; Histocytochemistry; Isoniazid/administration & dosage; Isoniazid/toxicity; Liver/pathology; Liver/physiopathology; Liver Function Tests; Male; Mice; Plant Extracts/isolation & purification; Plasma/chemistry; Plasma/enzymology; Pyrazinamide/administration & dosage; Pyrazinamide/toxicity; Rats, Wistar; Rifampin/administration & dosage; Rifampin/toxicity

Key words

Antihepatotoxicity; Antioxidant; Antitubercular drug; Biochemical parameter; Hepatoprotective effect; Histopathology; Isoniazid; Liver injury; Liver toxicity; Pyrazinamide; Rifampicin; Solanum xanthocarpum

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Full text: 1 Database: MEDLINE Complementary Medicines: Homeopatia Main subject: Gastrointestinal Agents / Plant Extracts / Solanum / Chemical and Drug Induced Liver Injury / Fruit / Antitubercular Agents Language: En Journal: Asian Pac J Trop Biomed Year: 2012 Type: Article

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