A new bioactive sesquiterpenoid quinone from the Mediterranean Sea marine sponge Dysidea avara.
Nat Prod Commun
; 8(3): 289-92, 2013 Mar.
Article
in En
| MEDLINE
| ID: mdl-23678793
ABSTRACT
Investigation of the marine sponge Dysidea avara, family Dysideidae, afforded a new sesquiterpene (-)-N-methylmelemeleone-A (5), in addition to four known sesquiterpenes (+)-avarol (1), (+)-avarone (2), (-)-3'-methylaminoavarone (3) and (-)-4'-methylaminoavarone (4). The structure elucidation of compound 5 was based on 1D and 2D NMR spectroscopic, and HR-MS studies, as well as by comparison with the literature. Cytotoxicity, proteinkinase inhibition, inhibition of NFkB-activity and insecticidal activity were evaluated for the isolated compounds.
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Database:
MEDLINE
Main subject:
Sesquiterpenes
/
Dysidea
Language:
En
Journal:
Nat Prod Commun
Year:
2013
Type:
Article
Affiliation country:
Germany