In vitro metabolism of brucine by human liver microsomes and its interactions with CYP substrates.

Li, Xin; Wang, Kai; Wei, Wei; Liu, Yong-yu; Gong, Lu

Li, Xin; Wang, Kai; Wei, Wei; Liu, Yong-yu; Gong, Lu.

Affiliation

Li X; Tianjin Medical University General Hospital, Department of Infectious Diseases and Immunology, Tianjin, 300052, China.

Chem Biol Interact ; 204(3): 140-3, 2013 Aug 25.

Article in En | MEDLINE | ID: mdl-23707193

Subject(s)

Cytochrome P-450 CYP3A/metabolism; Drugs, Chinese Herbal/metabolism; Microsomes, Liver/metabolism; Strychnine/analogs & derivatives; Biological Assay; Cells, Cultured; Drugs, Chinese Herbal/chemistry; Enzyme Activation/drug effects; Enzyme Inhibitors/pharmacokinetics; Humans; Hydroxylation/drug effects; Inhibitory Concentration 50; Kinetics; Midazolam/metabolism; Strychnine/chemistry; Strychnine/pharmacokinetics

Key words

Brucine; CYP3A4; Human liver microsome; Interaction; Metabolism

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Full text: 1 Database: MEDLINE Traditional Medicines: Medicinas_tradicionales_de_asia / Medicina_china Main subject: Strychnine / Microsomes, Liver / Drugs, Chinese Herbal / Cytochrome P-450 CYP3A Language: En Journal: Chem Biol Interact Year: 2013 Type: Article Affiliation country: China

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