A high-throughput functional screen identifies small molecule regulators of temperature- and mechano-sensitive K2P channels.

Bagriantsev, Sviatoslav N; Ang, Kean-Hooi; Gallardo-Godoy, Alejandra; Clark, Kimberly A; Arkin, Michelle R; Renslo, Adam R; Minor, Daniel L

Bagriantsev, Sviatoslav N; Ang, Kean-Hooi; Gallardo-Godoy, Alejandra; Clark, Kimberly A; Arkin, Michelle R; Renslo, Adam R; Minor, Daniel L.

Affiliation

Bagriantsev SN; Cardiovascular Research Institute, University of California, San Francisco, California 94158, United States.

ACS Chem Biol ; 8(8): 1841-51, 2013 Aug 16.

Article in En | MEDLINE | ID: mdl-23738709

Subject(s)

Biological Assay/methods; Drug Evaluation, Preclinical; Potassium Channels, Tandem Pore Domain/metabolism; Small Molecule Libraries/pharmacology; Temperature; Models, Biological; Molecular Structure; Potassium Channels, Tandem Pore Domain/chemistry; Protein Binding/drug effects; Yeasts/enzymology; Yeasts/genetics

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Full text: 1 Database: MEDLINE Main subject: Temperature / Biological Assay / Potassium Channels, Tandem Pore Domain / Drug Evaluation, Preclinical / Small Molecule Libraries Type of study: Diagnostic_studies Language: En Journal: ACS Chem Biol Year: 2013 Type: Article Affiliation country: United States

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