Rhododendrin ameliorates skin inflammation through inhibition of NF-&#954;B, MAPK, and PI3K/Akt signaling.

Jeon, Yoon-Jae; Kim, Byung-Hak; Kim, Sunghwan; Oh, Ikhoon; Lee, Sooryun; Shin, Jongheon; Kim, Tae-Yoon

Rhododendrin ameliorates skin inflammation through inhibition of NF-κB, MAPK, and PI3K/Akt signaling.

Jeon, Yoon-Jae; Kim, Byung-Hak; Kim, Sunghwan; Oh, Ikhoon; Lee, Sooryun; Shin, Jongheon; Kim, Tae-Yoon.

Affiliation

Jeon YJ; Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul 137-040, South Korea.

Eur J Pharmacol ; 714(1-3): 7-14, 2013 Aug 15.

Article in En | MEDLINE | ID: mdl-23764465

Subject(s)

Glycosides/pharmacology; MAP Kinase Signaling System/drug effects; NF-kappa B/metabolism; Phenols/pharmacology; Phosphatidylinositol 3-Kinases/metabolism; Proto-Oncogene Proteins c-akt/metabolism; Skin/drug effects; Skin/pathology; Animals; Anti-Inflammatory Agents/pharmacology; Anti-Inflammatory Agents/therapeutic use; Cell Line; Glycosides/therapeutic use; Humans; Inflammation/drug therapy; Inflammation/pathology; Mice; Phenols/therapeutic use; Plant Leaves/chemistry; Rhododendron/chemistry

Key words

Anti-inflammatory activity; Inflammatory skin disease; Keratinocyte; Rhododendrin

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Full text: 1 Database: MEDLINE Main subject: Phenols / Skin / NF-kappa B / Phosphatidylinositol 3-Kinases / MAP Kinase Signaling System / Proto-Oncogene Proteins c-akt / Glycosides Language: En Journal: Eur J Pharmacol Year: 2013 Type: Article Affiliation country: South Korea

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