Cantharidin and norcantharidin inhibit the ability of MCF-7 cells to adhere to platelets via protein kinase C pathway-dependent downregulation of &#945;2 integrin.

Shou, Liu-Mei; Zhang, Qiong-Yan; Li, Wei; Xie, Xin; Chen, Kai; Lian, Lian; Li, Zhen-Yu; Gong, Fei-Ran; Dai, Ke-Sheng; Mao, Yi-Xiang; Tao, Min

Cantharidin and norcantharidin inhibit the ability of MCF-7 cells to adhere to platelets via protein kinase C pathway-dependent downregulation of α2 integrin.

Shou, Liu-Mei; Zhang, Qiong-Yan; Li, Wei; Xie, Xin; Chen, Kai; Lian, Lian; Li, Zhen-Yu; Gong, Fei-Ran; Dai, Ke-Sheng; Mao, Yi-Xiang; Tao, Min.

Affiliation

Shou LM; Department of Oncology, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China.

Oncol Rep ; 30(3): 1059-66, 2013 Sep.

Article in En | MEDLINE | ID: mdl-23835679

Subject(s)

Blood Platelets/metabolism; Breast Neoplasms/drug therapy; Bridged Bicyclo Compounds, Heterocyclic/pharmacology; Cantharidin/pharmacology; Integrin alpha2/chemistry; Platelet Adhesiveness/drug effects; Protein Kinase C/metabolism; Apoptosis/drug effects; Blood Platelets/drug effects; Blotting, Western; Breast Neoplasms/metabolism; Breast Neoplasms/pathology; Cell Adhesion/drug effects; Cell Proliferation/drug effects; Down-Regulation; Enzyme Inhibitors/pharmacology; Female; Flow Cytometry; Humans; Integrin alpha2/genetics; Integrin alpha2/metabolism; MCF-7 Cells; Protein Kinase C/genetics; RNA, Messenger/genetics; RNA, Small Interfering/genetics; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factor RelA/antagonists & inhibitors; Transcription Factor RelA/genetics; Transcription Factor RelA/metabolism; Wound Healing/drug effects

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Full text: 1 Database: MEDLINE Traditional Medicines: Medicinas_tradicionales_de_asia / Medicina_china Main subject: Blood Platelets / Protein Kinase C / Breast Neoplasms / Cantharidin / Platelet Adhesiveness / Bridged Bicyclo Compounds, Heterocyclic / Integrin alpha2 Language: En Journal: Oncol Rep Year: 2013 Type: Article

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