In vitro antimicrobial activity of plant-derived diterpenes against bovine mastitis bacteria.
Molecules
; 18(7): 7865-72, 2013 Jul 04.
Article
in En
| MEDLINE
| ID: mdl-23884123
ABSTRACT
We evaluated the antibacterial activity of three diterpenes isolated from natural sources against a panel of microorganisms responsible for bovine mastitis. ent-Copalic acid (CA) was the most active metabolite, with promising MIC values (from 1.56 to 6.25 µg mL-1) against Staphylococcus aureus (ATCC and clinical isolate), Staphylococcus epidermidis, Streptococcus agalactiae, and Streptococcus dysgalactiae. We conducted time-kill assays of CA against S. aureus, a commensal organism considered to be a ubiquitous etiological agent of bovine mastitis in dairy farms worldwide. In the first 12 h, CA only inhibited the growth of the inoculums (bacteriostatic effect), but its bactericidal effect was clearly noted thereafter (between 12 and 24 h). In conclusion, CA should be considered for the control of several Gram-positive bacteria related to bovine mastitis.
Full text:
1
Database:
MEDLINE
Main subject:
Staphylococcus aureus
/
Diterpenes
/
Mastitis, Bovine
Language:
En
Journal:
Molecules
Year:
2013
Type:
Article
Affiliation country:
Brazil