Isoosmolar enemas demonstrate preferential gastrointestinal distribution, safety, and acceptability compared with hyperosmolar and hypoosmolar enemas as a potential delivery vehicle for rectal microbicides.

Leyva, Francisco J; Bakshi, Rahul P; Fuchs, Edward J; Li, Liye; Caffo, Brian S; Goldsmith, Arthur J; Ventuneac, Ana; Carballo-Diéguez, Alex; Du, Yong; Leal, Jeffrey P; Lee, Linda A; Torbenson, Michael S; Hendrix, Craig W

Leyva, Francisco J; Bakshi, Rahul P; Fuchs, Edward J; Li, Liye; Caffo, Brian S; Goldsmith, Arthur J; Ventuneac, Ana; Carballo-Diéguez, Alex; Du, Yong; Leal, Jeffrey P; Lee, Linda A; Torbenson, Michael S; Hendrix, Craig W.

Affiliation

Leyva FJ; 1 Department of Medicine, Johns Hopkins University School of Medicine , Baltimore, Maryland.

AIDS Res Hum Retroviruses ; 29(11): 1487-95, 2013 Nov.

Article in En | MEDLINE | ID: mdl-23885722

Subject(s)

Anti-Infective Agents/administration & dosage; Enema/adverse effects; Enema/methods; HIV Infections/prevention & control; Patient Acceptance of Health Care; Solutions/administration & dosage; Solutions/chemistry; Biopsy; Colon, Sigmoid/drug effects; Colon, Sigmoid/pathology; Humans; Intestinal Mucosa/drug effects; Intestinal Mucosa/pathology; Male; Solutions/pharmacokinetics; Tomography, Emission-Computed, Single-Photon

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Full text: 1 Database: MEDLINE Main subject: Solutions / Patient Acceptance of Health Care / HIV Infections / Enema / Anti-Infective Agents Type of study: Clinical_trials Language: En Journal: AIDS Res Hum Retroviruses Year: 2013 Type: Article

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