Lycium barbarum (wolfberry) reduces secondary degeneration and oxidative stress, and inhibits JNK pathway in retina after partial optic nerve transection.

Li, Hongying; Liang, Yuxiang; Chiu, Kin; Yuan, Qiuju; Lin, Bin; Chang, Raymond Chuen-Chung; So, Kwok-Fai

Li, Hongying; Liang, Yuxiang; Chiu, Kin; Yuan, Qiuju; Lin, Bin; Chang, Raymond Chuen-Chung; So, Kwok-Fai.

Affiliation

Li H; Department of Anatomy and the State Key Laboratory of Brain and Cognitive Science, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

PLoS One ; 8(7): e68881, 2013.

Article in En | MEDLINE | ID: mdl-23894366

Subject(s)

JNK Mitogen-Activated Protein Kinases/metabolism; Lycium/chemistry; Nerve Degeneration/etiology; Optic Nerve Injuries/complications; Optic Nerve Injuries/metabolism; Oxidative Stress/drug effects; Plant Extracts/pharmacology; Signal Transduction/drug effects; Animals; Cell Survival/drug effects; Female; Insulin-Like Growth Factor I/metabolism; Nerve Degeneration/drug therapy; Neuroprotective Agents/pharmacology; Plant Extracts/chemistry; Rats; Retina/drug effects; Retina/metabolism; Retina/pathology; Retinal Ganglion Cells/drug effects; Retinal Ganglion Cells/metabolism; Retinal Ganglion Cells/pathology; Time Factors

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Full text: 1 Database: MEDLINE Main subject: Plant Extracts / Signal Transduction / Oxidative Stress / Optic Nerve Injuries / Lycium / JNK Mitogen-Activated Protein Kinases / Nerve Degeneration Type of study: Prognostic_studies Language: En Journal: PLoS One Year: 2013 Type: Article Affiliation country: China

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