Gualou Xiebai Decoction prevents myocardial fibrosis by blocking TGF-beta/Smad signalling.

Ding, Yong-fang; Peng, Yun-ru; Li, Juan; Shen, Hong; Shen, Ming-qin; Fang, Tai-hui

Ding, Yong-fang; Peng, Yun-ru; Li, Juan; Shen, Hong; Shen, Ming-qin; Fang, Tai-hui.

Affiliation

Ding YF; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China.

J Pharm Pharmacol ; 65(9): 1373-81, 2013 Sep.

Article in En | MEDLINE | ID: mdl-23927476

Subject(s)

Cardiovascular Agents/pharmacology; Drugs, Chinese Herbal/pharmacology; Myocardial Infarction/pathology; Myocardium/metabolism; Phytotherapy; Smad Proteins/metabolism; Transforming Growth Factor beta1/antagonists & inhibitors; Allium; Animals; Cardiovascular Agents/therapeutic use; Collagen/metabolism; Drugs, Chinese Herbal/therapeutic use; Fibrosis; Heart Ventricles/drug effects; Inflammation/etiology; Inflammation/prevention & control; Male; Myocardial Infarction/drug therapy; Myocardium/pathology; Organ Size; Rats; Rats, Wistar; Signal Transduction; Smad Proteins/antagonists & inhibitors; Smad2 Protein/antagonists & inhibitors; Smad3 Protein/antagonists & inhibitors; Smad7 Protein/metabolism; Trichosanthes

Key words

Gualou Xiebai Decoction (GXD); myocardial fibrosis; myocardial infarction; transforming growth factor ß1

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Full text: 1 Database: MEDLINE Traditional Medicines: Medicinas_tradicionales_de_asia / Medicina_china Therapeutic Methods and Therapies TCIM: Terapias_biologicas Main subject: Drugs, Chinese Herbal / Cardiovascular Agents / Smad Proteins / Transforming Growth Factor beta1 / Phytotherapy / Myocardial Infarction / Myocardium Type of study: Etiology_studies Language: En Journal: J Pharm Pharmacol Year: 2013 Type: Article Affiliation country: China

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