Immunogenicity of a reduced-dose whole killed rabies vaccine is significantly enhanced by ISCOMATRIX&#8482; adjuvant, Merck amorphous aluminum hydroxylphosphate sulfate (MAA) or a synthetic TLR9 agonist in rhesus macaques.

DiStefano, Daniel; Antonello, Joseph M; Bett, Andrew J; Medi, Muneeswara B; Casimiro, Danilo R; ter Meulen, Jan

Immunogenicity of a reduced-dose whole killed rabies vaccine is significantly enhanced by ISCOMATRIX™ adjuvant, Merck amorphous aluminum hydroxylphosphate sulfate (MAA) or a synthetic TLR9 agonist in rhesus macaques.

DiStefano, Daniel; Antonello, Joseph M; Bett, Andrew J; Medi, Muneeswara B; Casimiro, Danilo R; ter Meulen, Jan.

Affiliation

DiStefano D; Department of Vaccine Basic Research, Merck Research Laboratories, West Point, PA, USA.

Vaccine ; 31(42): 4888-93, 2013 Oct 01.

Article in En | MEDLINE | ID: mdl-23941913

Subject(s)

Adjuvants, Immunologic/administration & dosage; Aluminum Compounds/administration & dosage; Cholesterol/administration & dosage; Phospholipids/administration & dosage; Rabies Vaccines/administration & dosage; Rabies Vaccines/immunology; Saponins/administration & dosage; Toll-Like Receptor 9/agonists; Animals; Antibodies, Neutralizing/blood; Antibodies, Viral/blood; Drug Combinations; Female; Injections, Intramuscular; Macaca mulatta; Male; Neutralization Tests; Phosphates/administration & dosage; Rabies/prevention & control; Sulfates/administration & dosage; Toll-Like Receptor 9/immunology; Vaccines, Inactivated/administration & dosage; Vaccines, Inactivated/immunology

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Full text: 1 Database: MEDLINE Main subject: Phospholipids / Saponins / Rabies Vaccines / Adjuvants, Immunologic / Cholesterol / Aluminum Compounds / Toll-Like Receptor 9 Language: En Journal: Vaccine Year: 2013 Type: Article Affiliation country: United States

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