Pomegranate seed oil prevents bone loss in a mice model of osteoporosis, through osteoblastic stimulation, osteoclastic inhibition and decreased inflammatory status.

Spilmont, Mélanie; Léotoing, Laurent; Davicco, Marie-Jeanne; Lebecque, Patrice; Mercier, Sylvie; Miot-Noirault, Elisabeth; Pilet, Paul; Rios, Laurent; Wittrant, Yohann; Coxam, Véronique

Spilmont, Mélanie; Léotoing, Laurent; Davicco, Marie-Jeanne; Lebecque, Patrice; Mercier, Sylvie; Miot-Noirault, Elisabeth; Pilet, Paul; Rios, Laurent; Wittrant, Yohann; Coxam, Véronique.

Affiliation

Spilmont M; INRA, UMR 1019, UNH, CRNH Auvergne, F-63009 Clermont-Ferrand, France; Equipe Alimentation, Squelette et Métabolismes, France; Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, F-63000 Clermont-Ferrand, France; Greentech SA, Biopôle, Clermont-Limagne, 63360 Saint Beauzire, France.

J Nutr Biochem ; 24(11): 1840-8, 2013 Nov.

Article in En | MEDLINE | ID: mdl-23953990

Subject(s)

Lythraceae/chemistry; Osteoporosis/prevention & control; Plant Oils/therapeutic use; Seeds/chemistry; Animals; Bone Density; Cell Line; Cell Proliferation; Disease Models, Animal; Female; Interleukin-1/biosynthesis; Interleukin-6/biosynthesis; Linolenic Acids/therapeutic use; Mice; Osteoblasts/drug effects; Osteoblasts/physiology; Osteoclasts/drug effects; Osteoclasts/physiology; Ovariectomy; Receptors, Interleukin-6/antagonists & inhibitors

Key words

Animal model; Cell lines; Nutritional prevention; Osteoporosis; Pomegranate seed oil

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Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Terapias_biologicas / Aromoterapia / Plantas_medicinales Main subject: Osteoporosis / Seeds / Plant Oils / Lythraceae Type of study: Prognostic_studies / Risk_factors_studies Language: En Journal: J Nutr Biochem Year: 2013 Type: Article Affiliation country: France

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