Preclinical characterization of GLS4, an inhibitor of hepatitis B virus core particle assembly.

Wu, Guoyi; Liu, Bo; Zhang, Yingjun; Li, Jing; Arzumanyan, Alla; Clayton, Marcia M; Schinazi, Raymond F; Wang, Zhaohe; Goldmann, Siegfried; Ren, Qingyun; Zhang, Faxhou; Feitelson, Mark A

Wu, Guoyi; Liu, Bo; Zhang, Yingjun; Li, Jing; Arzumanyan, Alla; Clayton, Marcia M; Schinazi, Raymond F; Wang, Zhaohe; Goldmann, Siegfried; Ren, Qingyun; Zhang, Faxhou; Feitelson, Mark A.

Affiliation

Wu G; Department of Biology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania, USA.

Antimicrob Agents Chemother ; 57(11): 5344-54, 2013 Nov.

Article in En | MEDLINE | ID: mdl-23959305

Subject(s)

Antiviral Agents/pharmacology; DNA, Viral/antagonists & inhibitors; Hepatitis B virus/drug effects; Hepatitis B, Chronic/drug therapy; Pyrimidines/pharmacology; Thiazoles/pharmacology; Viremia/drug therapy; Virion/drug effects; Animals; Antiviral Agents/chemical synthesis; Cell Line; DNA, Viral/biosynthesis; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Hepatitis B virus/growth & development; Hepatitis B virus/ultrastructure; Hepatitis B, Chronic/virology; Hepatocytes/drug effects; Hepatocytes/pathology; Hepatocytes/virology; Humans; Lamivudine/pharmacology; Male; Mice; Mice, Nude; Microbial Sensitivity Tests; Primary Cell Culture; Pyridines/pharmacology; Pyrimidines/chemical synthesis; Thiazoles/chemical synthesis; Viral Core Proteins/antagonists & inhibitors; Viral Core Proteins/metabolism; Viremia/virology; Virion/ultrastructure; Virus Replication/drug effects

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Antiviral Agents / Pyrimidines / Thiazoles / Viremia / Virion / DNA, Viral / Hepatitis B virus / Hepatitis B, Chronic Language: En Journal: Antimicrob Agents Chemother Year: 2013 Type: Article Affiliation country: United States

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google