The toll-like receptor agonist imiquimod is active against prions.

Oumata, Nassima; Nguyen, Phu Hai; Beringue, Vincent; Soubigou, Flavie; Pang, Yanhong; Desban, Nathalie; Massacrier, Catherine; Morel, Yannis; Paturel, Carine; Contesse, Marie-Astrid; Bouaziz, Serge; Sanyal, Suparna; Galons, Hervé; Blondel, Marc; Voisset, Cécile

Oumata, Nassima; Nguyen, Phu Hai; Beringue, Vincent; Soubigou, Flavie; Pang, Yanhong; Desban, Nathalie; Massacrier, Catherine; Morel, Yannis; Paturel, Carine; Contesse, Marie-Astrid; Bouaziz, Serge; Sanyal, Suparna; Galons, Hervé; Blondel, Marc; Voisset, Cécile.

Affiliation

Oumata N; Laboratoire de Chimie Organique 2, INSERM U1022, Université Paris Descartes, Paris, France.

PLoS One ; 8(8): e72112, 2013.

Article in En | MEDLINE | ID: mdl-23977222

Subject(s)

Aminoquinolines/pharmacology; Glutathione Peroxidase/metabolism; Peptide Termination Factors/metabolism; Prion Diseases/drug therapy; Prions/metabolism; Saccharomyces cerevisiae Proteins/metabolism; Saccharomyces cerevisiae/metabolism; Aminoquinolines/chemical synthesis; Animals; Cell Line; Drug Evaluation, Preclinical; Guanosine/analogs & derivatives; Guanosine/pharmacology; Humans; Imidazoles/pharmacology; Imiquimod; Membrane Glycoproteins/agonists; Membrane Glycoproteins/metabolism; Mice; PrPSc Proteins/metabolism; Prion Diseases/metabolism; Protein Folding; Saccharomyces cerevisiae/drug effects; Structure-Activity Relationship; Toll-Like Receptor 7/agonists; Toll-Like Receptor 7/metabolism; Toll-Like Receptor 8/agonists; Toll-Like Receptor 8/metabolism

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Full text: 1 Database: MEDLINE Main subject: Saccharomyces cerevisiae / Prions / Peptide Termination Factors / Prion Diseases / Saccharomyces cerevisiae Proteins / Glutathione Peroxidase / Aminoquinolines Type of study: Prognostic_studies Language: En Journal: PLoS One Year: 2013 Type: Article Affiliation country: France

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