Anti-interleukin-6 receptor antibody prevents systemic bone mass loss via reducing the number of osteoclast precursors in bone marrow in a collagen-induced arthritis model.

Tanaka, Keisuke; Hashizume, Misato; Mihara, Masahiko; Yoshida, Hiroto; Suzuki, Miho; Matsumoto, Yoshihiro

Tanaka, Keisuke; Hashizume, Misato; Mihara, Masahiko; Yoshida, Hiroto; Suzuki, Miho; Matsumoto, Yoshihiro.

Affiliation

Tanaka K; Product Research Department, Fuji-Gotemba Research Laboratories, Chugai Pharmaceutical Co. Ltd, Gotemba, Shizuoka, Japan.

Clin Exp Immunol ; 175(2): 172-80, 2014 Feb.

Article in En | MEDLINE | ID: mdl-24028747

Subject(s)

Arthritis, Experimental/immunology; Bone Resorption/metabolism; Interleukin-6/physiology; Osteoclasts/metabolism; Receptors, Lysosphingolipid/physiology; Animals; Antibodies, Monoclonal, Humanized/immunology; Bone Density/immunology; Bone Marrow Cells; Bone Resorption/immunology; Bone Resorption/prevention & control; Cell Movement; Collagen; Gene Expression; Inflammation/immunology; Lysophospholipids/metabolism; Male; Mice; Mice, Inbred DBA; Osteoclasts/cytology; RNA, Messenger/biosynthesis; Receptors, Interleukin-6/antagonists & inhibitors; Receptors, Lysosphingolipid/genetics; Sphingosine/analogs & derivatives; Sphingosine/metabolism; Sphingosine-1-Phosphate Receptors; Stem Cells/cytology

Key words

collagen-induced arthritis; interleukin-6; osteoclast; sphingosine-1-phosphate receptor 2

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Full text: 1 Database: MEDLINE Main subject: Osteoclasts / Arthritis, Experimental / Bone Resorption / Interleukin-6 / Receptors, Lysosphingolipid Type of study: Prognostic_studies Language: En Journal: Clin Exp Immunol Year: 2014 Type: Article Affiliation country: Japan

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