Compound K, a metabolite of ginseng saponin, inhibits colorectal cancer cell growth and induces apoptosis through inhibition of histone deacetylase activity.

Kang, Kyoung Ah; Piao, Mei Jing; Kim, Ki Cheon; Zheng, Jian; Yao, Cheng Wen; Cha, Ji Won; Kim, Hye Sun; Kim, Dong Hyun; Bae, Suk Chul; Hyun, Jin Won

Kang, Kyoung Ah; Piao, Mei Jing; Kim, Ki Cheon; Zheng, Jian; Yao, Cheng Wen; Cha, Ji Won; Kim, Hye Sun; Kim, Dong Hyun; Bae, Suk Chul; Hyun, Jin Won.

Affiliation

Kang KA; School of Medicine and Institute for Nuclear Science and Technology, Jeju National University, Jeju 690-756, Republic of Korea.

Int J Oncol ; 43(6): 1907-14, 2013 Dec.

Article in En | MEDLINE | ID: mdl-24100442

Subject(s)

Apoptosis/drug effects; Colorectal Neoplasms/drug therapy; Ginsenosides/pharmacology; Histone Deacetylase Inhibitors/pharmacology; Histone Deacetylases/metabolism; Acetylation/drug effects; Cell Line, Tumor; Cell Proliferation/drug effects; Core Binding Factor Alpha 3 Subunit/genetics; Core Binding Factor Alpha 3 Subunit/metabolism; Cyclin-Dependent Kinase Inhibitor p21/genetics; DNA-Binding Proteins/metabolism; G1 Phase Cell Cycle Checkpoints/drug effects; Gene Expression Regulation, Neoplastic/drug effects; HT29 Cells; Histone Deacetylases/drug effects; Histones/metabolism; Humans; Hydroxamic Acids/pharmacology; Panax; Promoter Regions, Genetic/drug effects; Promoter Regions, Genetic/genetics; Protein Binding/drug effects; RNA, Messenger/biosynthesis

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Full text: 1 Database: MEDLINE Main subject: Colorectal Neoplasms / Apoptosis / Ginsenosides / Histone Deacetylase Inhibitors / Histone Deacetylases Language: En Journal: Int J Oncol Year: 2013 Type: Article

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