Uncoupling of eNOS contributes to redox-sensitive leukocyte recruitment and microvascular leakage elicited by methylglyoxal.

Su, Yang; Qadri, Syed M; Hossain, Mokarram; Wu, Lingyun; Liu, Lixin

Su, Yang; Qadri, Syed M; Hossain, Mokarram; Wu, Lingyun; Liu, Lixin.

Affiliation

Su Y; Department of Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada S7N 5E5.

Biochem Pharmacol ; 86(12): 1762-74, 2013 Dec 15.

Article in En | MEDLINE | ID: mdl-24144633

Subject(s)

Capillary Permeability/drug effects; Leukocytes/cytology; Nitric Oxide Synthase Type III/metabolism; Pyruvaldehyde/pharmacology; Animals; Biopterins/analogs & derivatives; Biopterins/metabolism; Leukocytes/metabolism; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal/drug effects; Muscle, Skeletal/metabolism; Oxidation-Reduction; Reactive Oxygen Species/metabolism

Key words

Leukocyte recruitment; Methylglyoxal; Microvascular permeability; Superoxide; eNOS uncoupling

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Full text: 1 Database: MEDLINE Main subject: Pyruvaldehyde / Capillary Permeability / Nitric Oxide Synthase Type III / Leukocytes Type of study: Diagnostic_studies Language: En Journal: Biochem Pharmacol Year: 2013 Type: Article

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