Mechanisms of neuroprotection by glucose in rat retinal cell cultures subjected to respiratory inhibition.

Han, Guoge; Wood, John P M; Chidlow, Glyn; Mammone, Teresa; Casson, Robert J

Han, Guoge; Wood, John P M; Chidlow, Glyn; Mammone, Teresa; Casson, Robert J.

Affiliation

Han G; Ophthalmic Research Laboratories, South Australian Institute of Ophthalmology, Hanson Institute Centre for Neurological Diseases, Adelaide, Australia.

Invest Ophthalmol Vis Sci ; 54(12): 7567-77, 2013 Nov 15.

Article in En | MEDLINE | ID: mdl-24150756

Subject(s)

Glucose/pharmacology; Neuroglia/cytology; Retinal Neurons/cytology; Sweetening Agents/pharmacology; Adenosine Triphosphate/metabolism; Animals; Animals, Newborn; Blotting, Western; Cell Survival/drug effects; Cells, Cultured; Cytoprotection/drug effects; Dose-Response Relationship, Drug; Electron Transport Complex I/antagonists & inhibitors; Fluorescent Antibody Technique, Indirect; Glycolysis/drug effects; In Situ Nick-End Labeling; NADP/metabolism; Neuroglia/drug effects; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species/metabolism; Retinal Neurons/drug effects; Rotenone/toxicity; Uncoupling Agents/toxicity

Key words

experimental anoxia; glucose; glycolysis; neuroprotection; pentose phosphate pathway; rotenone

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Full text: 1 Database: MEDLINE Main subject: Sweetening Agents / Neuroglia / Retinal Neurons / Glucose Language: En Journal: Invest Ophthalmol Vis Sci Year: 2013 Type: Article Affiliation country: Australia

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