Peripheral immunomodulation with ginsenoside Rg1 ameliorates neuroinflammation-induced behavioral deficits in rats.

Zheng, X; Liang, Y; Kang, A; Ma, S-J; Xing, L; Zhou, Y-Y; Dai, C; Xie, H; Xie, L; Wang, G-J; Hao, H-P

Zheng, X; Liang, Y; Kang, A; Ma, S-J; Xing, L; Zhou, Y-Y; Dai, C; Xie, H; Xie, L; Wang, G-J; Hao, H-P.

Affiliation

Zheng X; State Key Laboratory of Natural Medicines, Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, PR China; Department of Pharmaceutical Preparation, Jiangsu Province Hospital of Chinese Medicine, Nanjing 210029, PR China.
Liang Y; State Key Laboratory of Natural Medicines, Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, PR China.
Kang A; State Key Laboratory of Natural Medicines, Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, PR China; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, PR China.
Ma SJ; State Key Laboratory of Natural Medicines, Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, PR China.
Xing L; State Key Laboratory of Natural Medicines, Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, PR China.
Zhou YY; State Key Laboratory of Natural Medicines, Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, PR China.
Dai C; State Key Laboratory of Natural Medicines, Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, PR China.
Xie H; State Key Laboratory of Natural Medicines, Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, PR China.
Xie L; State Key Laboratory of Natural Medicines, Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, PR China.
Wang GJ; State Key Laboratory of Natural Medicines, Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, PR China. Electronic address: guangjiwang@hotmail.com.
Hao HP; State Key Laboratory of Natural Medicines, Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, PR China. Electronic address: hhp_770505@yahoo.com.cn.

Neuroscience ; 256: 210-22, 2014 Jan 03.

Article in En | MEDLINE | ID: mdl-24161284

Subject(s)

Central Nervous System Agents/therapeutic use; Encephalitis/complications; Ginsenosides/therapeutic use; Mental Disorders/drug therapy; Mental Disorders/etiology; Analysis of Variance; Animals; Body Weight/drug effects; Cytokines/genetics; Cytokines/metabolism; Disease Models, Animal; Dose-Response Relationship, Drug; Eating/drug effects; Encephalitis/chemically induced; Enzyme-Linked Immunosorbent Assay; Food Preferences/drug effects; Lipopolysaccharides/toxicity; Male; Mental Disorders/immunology; Minocycline/therapeutic use; Rats; Rats, Wistar; Serotonin/metabolism

Key words

5-HIAA; 5-HT; 5-hydroxyindoleacetic acid; BBB; BDNF; CNS drug discovery; COX-2; EDTA; ELISA; HPA; ICAM-1; IL; Iba-1; KA; KYN; LCMS; LPS; MMPs; MPO; Mino; Myeloperoxidase; Rg1; TNF; bloodbrain barrier; brain-derived neurotrophin factor; cyclooxygenase-2; depression; enzyme-linked immunosorbent assay; ethylenediaminetetraacetic acid; ginsenoside Rg1; hypothalamicpituitaryadrenal; iNOS; inducible nitric oxide synthase; interleukin; intracellular adhesion molecule 1; ionized calcium-binding adaptor molecule-1; kynurenic acid; kynurenine; lipopolysaccharide; liquid chromatographymass spectrometry; matrix metalloproteinases; microglia; minocycline; neuroinflammation; peripheral target; qPCR; quantitative PCR; serotonin; tumor necrosis factor

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Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Plantas_medicinales Main subject: Central Nervous System Agents / Ginsenosides / Encephalitis / Mental Disorders Type of study: Diagnostic_studies / Prognostic_studies Language: En Journal: Neuroscience Year: 2014 Type: Article

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