In vitro inhibition of metabolism but not transport of gliclazide and repaglinide by Cree medicinal plant extracts.

Cieniak, Carolina; Liu, Rui; Fottinger, Alexandra; Smiley, Sheila A M; Guerrero-Analco, Jose A; Bennett, Steffany A L; Haddad, Pierre S; Cuerrier, Alain; Saleem, Ammar; Arnason, John T; Foster, Brian C

Cieniak, Carolina; Liu, Rui; Fottinger, Alexandra; Smiley, Sheila A M; Guerrero-Analco, Jose A; Bennett, Steffany A L; Haddad, Pierre S; Cuerrier, Alain; Saleem, Ammar; Arnason, John T; Foster, Brian C.

Affiliation

Cieniak C; Biology Department, University of Ottawa, Ottawa, Ontario, Canada K1N 6N5.

J Ethnopharmacol ; 150(3): 1087-95, 2013 Dec 12.

Article in En | MEDLINE | ID: mdl-24184081

Subject(s)

Carbamates/pharmacology; Gliclazide/pharmacology; Hypoglycemic Agents/pharmacology; Piperidines/pharmacology; Plant Extracts/pharmacology; Aryl Hydrocarbon Hydroxylases/antagonists & inhibitors; Aryl Hydrocarbon Hydroxylases/metabolism; Caco-2 Cells; Drug Interactions; Glucuronosyltransferase/metabolism; Humans; Intestinal Absorption; Medicine, Traditional; Microsomes, Liver/metabolism; Plants, Medicinal; Quebec; Stilbenes/metabolism

Key words

Caco-2; Cytochrome P450; Disposition; Drug interaction; Traditional medicine

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Terapias_biologicas / Plantas_medicinales Main subject: Piperidines / Carbamates / Plant Extracts / Gliclazide / Hypoglycemic Agents Country/Region as subject: America do norte Language: En Journal: J Ethnopharmacol Year: 2013 Type: Article

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google