Epigallocatechin-3-gallate attenuates Porphyromonas gingivalis lipopolysaccharide-enhanced matrix metalloproteinase-1 production through inhibition of interleukin-6 in gingival fibroblasts.

Wen, Wan-Chun; Kuo, Po-Jan; Chiang, Cheng-Yang; Chin, Yu-Tang; Fu, Martin M J; Fu, Earl

Wen, Wan-Chun; Kuo, Po-Jan; Chiang, Cheng-Yang; Chin, Yu-Tang; Fu, Martin M J; Fu, Earl.

Affiliation

Wen WC; Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri-Service General Hospital, Taipei, Taiwan, ROC.

J Periodontol ; 85(6): 868-75, 2014 Jun.

Article in En | MEDLINE | ID: mdl-24215203

Subject(s)

Antioxidants/pharmacology; Catechin/analogs & derivatives; Fibroblasts/drug effects; Gingiva/drug effects; Interleukin-6/antagonists & inhibitors; Lipopolysaccharides/pharmacology; Matrix Metalloproteinase 1/drug effects; Matrix Metalloproteinase Inhibitors/pharmacology; Porphyromonas gingivalis/drug effects; Adult; Antioxidants/toxicity; Catechin/pharmacology; Catechin/toxicity; Cell Culture Techniques; Cell Survival/drug effects; Cells, Cultured; Female; Gingiva/cytology; Humans; Interleukin-6/analysis; Male; Matrix Metalloproteinase 1/analysis; Matrix Metalloproteinase Inhibitors/toxicity; Microscopy, Confocal; NF-kappa B/drug effects; Young Adult

Key words

Epigallocatechin gallate; fibroblasts; gingiva; interleukin-6; lipopolysaccharides; matrix metalloproteinase 1

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Full text: 1 Database: MEDLINE Main subject: Catechin / Lipopolysaccharides / Interleukin-6 / Porphyromonas gingivalis / Matrix Metalloproteinase 1 / Fibroblasts / Matrix Metalloproteinase Inhibitors / Gingiva / Antioxidants Language: En Journal: J Periodontol Year: 2014 Type: Article

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