Celastrol increases glucocerebrosidase activity in Gaucher disease by modulating molecular chaperones.

Yang, Chunzhang; Swallows, Cody L; Zhang, Chao; Lu, Jie; Xiao, Hongbin; Brady, Roscoe O; Zhuang, Zhengping

Yang, Chunzhang; Swallows, Cody L; Zhang, Chao; Lu, Jie; Xiao, Hongbin; Brady, Roscoe O; Zhuang, Zhengping.

Affiliation

Yang C; Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1260.

Proc Natl Acad Sci U S A ; 111(1): 249-54, 2014 Jan 07.

Article in En | MEDLINE | ID: mdl-24351928

Subject(s)

Gaucher Disease/metabolism; Glucosylceramidase/metabolism; Molecular Chaperones/chemistry; Triterpenes/pharmacology; Adaptor Proteins, Signal Transducing/metabolism; Apoptosis Regulatory Proteins; Catalysis; Cell Cycle Proteins/metabolism; Chaperonins/metabolism; Fibroblasts/metabolism; Gaucher Disease/genetics; Gene Expression Regulation, Enzymologic/drug effects; Glucosylceramidase/genetics; HSP70 Heat-Shock Proteins/metabolism; HSP90 Heat-Shock Proteins/metabolism; HeLa Cells; Humans; Mutation; Pentacyclic Triterpenes; Plant Preparations/pharmacology; Protein Binding; Protein Denaturation; Protein Folding; RNA Interference; Real-Time Polymerase Chain Reaction

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Full text: 1 Database: MEDLINE Main subject: Triterpenes / Molecular Chaperones / Gaucher Disease / Glucosylceramidase Language: En Journal: Proc Natl Acad Sci U S A Year: 2014 Type: Article

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