Small molecule SIRT1 activators for the treatment of aging and age-related diseases.

Hubbard, Basil P; Sinclair, David A

Hubbard, Basil P; Sinclair, David A.

Affiliation

Hubbard BP; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Sinclair DA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Department of Pharmacology, School of Medical Sciences, The University of New South Wales, Sydney, NSW 2052, Australia. Electronic address: david_sinclair@hms.harvard.edu.

Trends Pharmacol Sci ; 35(3): 146-54, 2014 Mar.

Article in En | MEDLINE | ID: mdl-24439680

Subject(s)

Aging/drug effects; Sirtuin 1/metabolism; Aging/metabolism; Aging/pathology; Animals; Cardiovascular Diseases/drug therapy; Cardiovascular Diseases/metabolism; Diabetes Mellitus/drug therapy; Diabetes Mellitus/metabolism; Humans; Inflammation/drug therapy; Inflammation/metabolism; Longevity/drug effects; Longevity/physiology; Molecular Targeted Therapy; Neoplasms/drug therapy; Neoplasms/metabolism

Key words

STAC; aging; allosteric activator; cancer; cardiovascular disease; chromatin; deacetylase; diabetes; inflammation; sirtuin

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Aging / Sirtuin 1 Language: En Journal: Trends Pharmacol Sci Year: 2014 Type: Article Affiliation country: United States

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Aging / Sirtuin 1 Language: En Journal: Trends Pharmacol Sci Year: 2014 Type: Article Affiliation country: United States