GPI/AMF inhibition blocks the development of the metastatic phenotype of mature multi-cellular tumor spheroids.

Gallardo-Pérez, Juan Carlos; Rivero-Segura, Nadia Alejandra; Marín-Hernández, Alvaro; Moreno-Sánchez, Rafael; Rodríguez-Enríquez, Sara

Gallardo-Pérez, Juan Carlos; Rivero-Segura, Nadia Alejandra; Marín-Hernández, Alvaro; Moreno-Sánchez, Rafael; Rodríguez-Enríquez, Sara.

Affiliation

Gallardo-Pérez JC; Departamento de Bioquímica, Instituto Nacional de Cardiología, Tlalpan, México DF 14080, México.
Rivero-Segura NA; Departamento de Bioquímica, Instituto Nacional de Cardiología, Tlalpan, México DF 14080, México.
Marín-Hernández A; Departamento de Bioquímica, Instituto Nacional de Cardiología, Tlalpan, México DF 14080, México.
Moreno-Sánchez R; Departamento de Bioquímica, Instituto Nacional de Cardiología, Tlalpan, México DF 14080, México.
Rodríguez-Enríquez S; Departamento de Bioquímica, Instituto Nacional de Cardiología, Tlalpan, México DF 14080, México; Laboratorio de Medicina Traslacional, Instituto Nacional de Cancerología, México. Electronic address: saren960201@hotmail.com.

Biochim Biophys Acta ; 1843(6): 1043-53, 2014 Jun.

Article in En | MEDLINE | ID: mdl-24440856

Subject(s)

Breast Neoplasms/prevention & control; Carcinoma, Ductal, Breast/prevention & control; Cell Movement/drug effects; Gluconates/pharmacology; Glucose-6-Phosphate Isomerase/antagonists & inhibitors; Spheroids, Cellular/drug effects; Sugar Phosphates/pharmacology; 3T3 Cells; Adult; Aged; Aged, 80 and over; Animals; Blotting, Western; Breast Neoplasms/metabolism; Breast Neoplasms/pathology; Carcinoma, Ductal, Breast/metabolism; Carcinoma, Ductal, Breast/secondary; Cell Proliferation/drug effects; Cross-Sectional Studies; Cytokines/antagonists & inhibitors; Cytokines/metabolism; Epithelial-Mesenchymal Transition/drug effects; Female; Glucose-6-Phosphate Isomerase/metabolism; Humans; Lactic Acid/metabolism; MCF-7 Cells; Mice; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Phenotype; Spheroids, Cellular/pathology

Key words

Cell migration; Epithelialmesenchymal transition; Glucose phosphate isomerase/autocrine motility factor; Invasiveness; Metastatic phenotype; Tumor spheroid

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Full text: 1 Database: MEDLINE Main subject: Sugar Phosphates / Breast Neoplasms / Cell Movement / Carcinoma, Ductal, Breast / Spheroids, Cellular / Gluconates / Glucose-6-Phosphate Isomerase Type of study: Observational_studies / Prevalence_studies / Risk_factors_studies Language: En Journal: Biochim Biophys Acta Year: 2014 Type: Article

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