Bioactivation of 3-n-butylphthalide via sulfation of its major metabolite 3-hydroxy-NBP: mediated mainly by sulfotransferase 1A1.

Diao, Xingxing; Pang, Xiaoyan; Xie, Cen; Guo, Zitao; Zhong, Dafang; Chen, Xiaoyan

Diao, Xingxing; Pang, Xiaoyan; Xie, Cen; Guo, Zitao; Zhong, Dafang; Chen, Xiaoyan.

Affiliation

Diao X; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People's Republic of China.

Drug Metab Dispos ; 42(4): 774-81, 2014 Apr.

Article in En | MEDLINE | ID: mdl-24468743

Subject(s)

Arylsulfotransferase/metabolism; Benzofurans/metabolism; Neuroprotective Agents/metabolism; Sulfur Compounds/metabolism; Acetylcysteine/metabolism; Animals; Benzofurans/pharmacokinetics; Benzofurans/toxicity; Biotransformation; Cell Survival/drug effects; Cells, Cultured; Cytosol/enzymology; Cytosol/metabolism; Dose-Response Relationship, Drug; Glutathione/metabolism; Hepatocytes/drug effects; Humans; Hydroxylation; Kidney/enzymology; Kidney/metabolism; Liver/enzymology; Liver/metabolism; Male; Microsomes, Liver/enzymology; Microsomes, Liver/metabolism; Neuroprotective Agents/pharmacokinetics; Neuroprotective Agents/toxicity; Rats; Rats, Sprague-Dawley

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Full text: 1 Database: MEDLINE Main subject: Sulfur Compounds / Benzofurans / Arylsulfotransferase / Neuroprotective Agents Language: En Journal: Drug Metab Dispos Year: 2014 Type: Article

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