Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-&#954;B regulated gene products in multiple myeloma xenograft mouse model.

Siveen, Kodappully Sivaraman; Mustafa, Nurulhuda; Li, Feng; Kannaiyan, Radhamani; Ahn, Kwang Seok; Kumar, Alan Prem; Chng, Wee-Joo; Sethi, Gautam

Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-κB regulated gene products in multiple myeloma xenograft mouse model.

Siveen, Kodappully Sivaraman; Mustafa, Nurulhuda; Li, Feng; Kannaiyan, Radhamani; Ahn, Kwang Seok; Kumar, Alan Prem; Chng, Wee-Joo; Sethi, Gautam.

Affiliation

Siveen KS; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Oncotarget ; 5(3): 634-48, 2014 Feb 15.

Article in En | MEDLINE | ID: mdl-24504138

Subject(s)

Antineoplastic Combined Chemotherapy Protocols/pharmacology; Benzoquinones/pharmacology; Boronic Acids/pharmacology; Multiple Myeloma/drug therapy; NF-kappa B/genetics; Pyrazines/pharmacology; Animals; Apoptosis/drug effects; Benzoquinones/administration & dosage; Boronic Acids/administration & dosage; Bortezomib; Cell Line, Tumor; Cell Proliferation/drug effects; Disease Models, Animal; Drug Synergism; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Multiple Myeloma/genetics; Multiple Myeloma/metabolism; Multiple Myeloma/pathology; NF-kappa B/metabolism; Pyrazines/administration & dosage; Random Allocation; Signal Transduction; Xenograft Model Antitumor Assays

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Full text: 1 Database: MEDLINE Main subject: Pyrazines / Boronic Acids / Antineoplastic Combined Chemotherapy Protocols / Benzoquinones / NF-kappa B / Multiple Myeloma Type of study: Clinical_trials / Prognostic_studies Language: En Journal: Oncotarget Year: 2014 Type: Article Affiliation country: Singapore

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