Bioenergetic properties of human sarcoma cells help define sensitivity to metabolic inhibitors.

Issaq, Sameer H; Teicher, Beverly A; Monks, Anne

Issaq, Sameer H; Teicher, Beverly A; Monks, Anne.

Affiliation

Issaq SH; Molecular Pharmacology Branch; Leidos Biomedical Research, Inc.; Frederick National Laboratory for Cancer Research; Frederick, MD USA.
Teicher BA; Division of Cancer Treatment and Diagnosis; National Cancer Institute; Rockville, MD USA.
Monks A; Molecular Pharmacology Branch; Leidos Biomedical Research, Inc.; Frederick National Laboratory for Cancer Research; Frederick, MD USA.

Cell Cycle ; 13(7): 1152-61, 2014.

Article in En | MEDLINE | ID: mdl-24553119

Subject(s)

Bone Neoplasms/metabolism; Energy Metabolism/drug effects; Osteosarcoma/metabolism; Bone Neoplasms/pathology; Cell Line, Tumor; Cell Proliferation/drug effects; Cell Respiration/drug effects; Deoxyglucose/pharmacology; Electron Transport Complex I/antagonists & inhibitors; Glycolysis/drug effects; Humans; Hypoglycemic Agents/pharmacology; Metformin/pharmacology; Mitochondria/drug effects; Mitochondria/metabolism; Mitochondrial Proton-Translocating ATPases/antagonists & inhibitors; Oligomycins/pharmacology; Osteosarcoma/pathology

Key words

2-DG; bioenergetics; metformin; osteosarcoma; rhabdomyosarcoma; sarcoma

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Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Terapias_energeticas / Bioenergetica Main subject: Bone Neoplasms / Osteosarcoma / Energy Metabolism Type of study: Diagnostic_studies / Prognostic_studies Language: En Journal: Cell Cycle Year: 2014 Type: Article

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